Understanding MARCoNS: Definition and Procedures for Correction

MARCoNS, or Multiple Antibiotic Resistant Coagulase-Negative Staphylococci, is a type of bacteria often found in the nasal passages of individuals with Chronic Inflammatory Response Syndrome (CIRS). This condition is particularly prevalent in patients exposed to biotoxins such as mold, actinomyces, and endotoxins. MARCoNS plays a significant role in perpetuating inflammation and immune dysfunction, making its identification and treatment critical for recovery.

What is MARCoNS?

MARCoNS is a biofilm-forming bacterial colony that resides in the sinuses and nasal passages. It is characterized by its resistance to multiple antibiotics and its ability to evade detection and treatment due to its protective biofilm. This biofilm acts as a shield, making it difficult for medications to penetrate and eradicate the bacteria.

Key Characteristics of MARCoNS

• Antibiotic Resistance: MARCoNS are resistant to most antibiotics, complicating treatment.

• Biofilm Formation: These bacteria produce a biofilm that protects them from immune responses and treatments.

• Immune Suppression: MARCoNS can suppress melanocyte-stimulating hormone (MSH), an important regulator of the immune system, leading to chronic inflammation.

• Association with CIRS: MARCoNS is commonly found in individuals suffering from CIRS, particularly those exposed to mold or other biotoxins.

Procedures to Correct MARCoNS

Addressing MARCoNS involves a multi-step approach that includes testing, treatment, and environmental management. Below is an expanded guide to each step.

1. Testing for MARCoNS

Before initiating treatment, it is essential to confirm the presence of MARCoNS through proper diagnostic tests:

• Nasal Swab Culture: A deep nasal swab can be sent to specialized labs for analysis. The test identifies the presence of coagulase-negative staphylococci and assesses its antibiotic resistance profile.

• Genie Test: This genetic test can help determine whether MARCoNS contributes to CIRS symptoms by evaluating immune markers like MSH.

2. Treatment Protocols

The treatment of MARCoNS typically follows Dr. Shoemaker’s protocol, which emphasizes eradicating the bacteria while addressing underlying inflammation.

A. Nasal Antimicrobials

• Use prescription nasal sprays containing antimicrobial agents such as:

  • BEG Spray: A combination of Bactroban (mupirocin), EDTA (to break down biofilms), and gentamicin.

  • Follow the prescribed dosage, typically 2 sprays per nostril 2–3 times daily for several weeks.

• Ensure proper technique:

  • Tilt your head back slightly when spraying.

  • Avoid blowing your nose immediately after application.

B. Biofilm Disruption

• The biofilm surrounding MARCoNS must be dissolved for effective treatment:

  • EDTA (ethylenediaminetetraacetic acid) in BEG spray helps break down biofilms.

  • Supplements like N-acetylcysteine (NAC) may also support biofilm disruption.

C. Anti-Inflammatory Support

• Address systemic inflammation caused by MARCoNS:

  • Cholestyramine or Welchol may be prescribed to bind biotoxins and reduce their impact on the immune system.

  • Anti-inflammatory supplements such as omega-3 fatty acids or curcumin may provide additional support.

D. Immune System Recovery

• Restore MSH levels through lifestyle changes and supplements:

  • Optimize sleep patterns.

  • Reduce stress through mindfulness or meditation.

  • Consider melatonin supplementation under medical supervision.

3. Environmental Management

Treating MARCoNS without addressing environmental factors often leads to reinfection. Mold exposure, in particular, must be eliminated.

A. Mold Remediation

• Test your environment using ERMI or HERTSMI scoring systems.

• If mold levels are high:

  • Remediate visible mold using professional services.

  • Use HEPA air filters capable of capturing particles as small as 0.007 microns.

  • Maintain indoor humidity below 60% using dehumidifiers.

B. Cleaning Protocols

• Follow rigorous cleaning routines to remove actinomyces and other biotoxins:

  • Vacuum with a HEPA vacuum weekly.

  • Dust surfaces with electrostatic cloths dampened with a cleaning solution (e.g., Seventh Generation Free & Clear Dish Soap mixed with water).

  • Wash bedding frequently in hot water with Borax and vinegar.

C. Personal Hygiene

• Shower daily with soap to remove skin cells that feed actinomyces (a common co-factor in CIRS).

• Replace pillows every six months or use washable options like shredded foam pillows.

4. Monitoring Progress

After completing treatment, follow up with your healthcare provider to ensure eradication:

• Repeat nasal swab cultures to confirm that MARCoNS has been eliminated.

• Monitor CIRS symptoms for improvement, including reductions in inflammation and fatigue.

Final Thoughts

MARCoNS is a persistent bacterial infection that can significantly impact individuals with CIRS. By combining targeted medical treatments with environmental remediation and personal hygiene practices, patients can successfully eradicate this infection and reduce chronic inflammation. Consistency in following these protocols is key to long-term recovery.