CIRS Supplement Guide

DISCLAIMER: Please note that the information shared here has not been evaluated by the Food & Drug Administration or any other medical body. We do not aim to diagnose, treat, cure, or prevent any illness or disease. This information is intended for educational purposes only and should not be interpreted as medical advice or treatment recommendations.

Overview

We recommend that you do not purchase supplements from Amazon, as they are often sold by third-party vendors rather than Amazon, and quality control is sometimes compromised.

Foundational Support

1. Thorne Basic B Complex: B vitamins are essential for energy production and neurological function. They may help alleviate fatigue and cognitive symptoms associated with CIRS.
2. Thorne Magnesium CitraMate: Magnesium is crucial for over 300 enzymatic reactions in the body. It may help with muscle tension, sleep, and energy production.
3. Multi-mineral (Good State Ionic Minerals, Thorne Bio-Mins): Minerals are essential cofactors for many bodily functions and may be depleted in CIRS patients.
4. Vitamin C: A powerful antioxidant that supports immune function and may help combat oxidative stress in CIRS.
5. Vitamin D3+K2: Vitamin D is crucial for immune function and may be low in CIRS patients. K2 helps with proper calcium utilization.
6. Fish Oil / Omega 3 Complex: Omega-3 fatty acids have anti-inflammatory properties and support brain health.
7. Elete Electrolytes: Proper hydration and electrolyte balance are important for overall health and may be disrupted in CIRS.

Lipid Replacement

Lipids are a major component of our body’s cell membranes, and in CIRS they can become damaged and oxidized. Lipid replacement therapy may help improve energy production, nutrient absorption, and general function.

1. BodyBio PC (liposomal phospholipid complex)
2. BodyBio Balance Oil
3. Daily consumption of extra-virgin olive oil

Inflammation Management

Inflammation is a major component of CIRS. These supplements may help reduce inflammation and improve CIRS symptoms:

1. Metagenics Inflavanoid Intensive Care
2. Metagenics SPM Active
3. Boswellia: An herbal extract with anti-inflammatory properties.
4. Longvida Curcumin: A form of curcumin that may cross the blood-brain barrier, potentially providing additional anti-inflammatory benefits for the brain.
5. Resveratrol: A polyphenol with antioxidant and anti-inflammatory properties.

Gut Support

1. SBI Protect (Immunoglobulins): May help support gut barrier function.
2. BodyBio Butyrate: Supports gut health and may have anti-inflammatory properties.
3. Lauricidin: A form of monolaurin that may have antimicrobial properties.
4. Candex: An enzyme formula that may help manage Candida overgrowth if suspected.

Detoxification Support

1. S-Acetyl Glutathione: A form of glutathione that may support detoxification processes.
2. Molybdenum: May help process acetaldehyde produced by Candida die-off.
3. Biocidin Botanicals GI Detox: A blend of herbs and binders that may support detoxification.
4. Milk Thistle: An herb that may support liver function and detoxification.
5. Dandelion Root: May support liver function and detoxification.

Histamine/MCAS Support

1. Alpha-Glycosyl Isoquercitrin: A form of quercetin that may help stabilize mast cells.
2. DAO Enzyme: May help break down histamine when taken before high-histamine meals.
3. Spirulina: May have anti-inflammatory and antioxidant properties.
4. Resveratrol: May help modulate mast cell activity.

Metabolic (Energy) Support

1. Acetyl L-Carnitine: May support mitochondrial function and energy production.
2. CoQ10: An important cofactor in energy production.
3. PQQ: May support mitochondrial function and energy production.
4. D-Ribose: A sugar that plays a role in energy production.
5. Creatine: May support energy production, particularly in muscle and brain tissue.

Brain Support

1. Follow the Lipid Replacement, Foundational, and Inflammation Management protocols.
2. Synapsin Nasal Spray (prescription): May support brain health and cognitive function.

Sleep Support

1. Life Extension Liquid Melatonin: May help regulate sleep-wake cycles.
2. Valerian: An herb that may promote relaxation and sleep.
3. Glycine: An amino acid that may improve sleep quality.
4. Passionflower: An herb that may have calming effects.
5. Taurine: An amino acid that may support relaxation.
6. Magnesium L-Threonate: A form of magnesium that may cross the blood-brain barrier and support sleep.

Stress Support

1. L-Theanine: An amino acid that may promote relaxation without sedation.
2. Relora: A proprietary blend of plant extracts that may help manage stress.
3. Holy Basil: An adaptogenic herb that may help the body manage stress.

Anti-Viral Support

1. L-Lysine: An amino acid that may support immune function.
2. Lauricidin: A form of monolaurin that may have antimicrobial properties.

Important Note: While these supplements may be beneficial for some individuals with CIRS, it’s crucial to work with a healthcare provider familiar with CIRS to develop a personalized treatment plan. The effectiveness and safety of these supplements can vary depending on individual circumstances, and some may interact with medications or have contraindications for certain health conditions.

Citations

1. https://pubmed.ncbi.nlm.nih.gov/35842756/
2. https://www.semanticscholar.org/paper/d079e4fbca0a12d9d412cd250f507ff04918fcc9
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645761/
4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10746024/
5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8685478/
6. https://www.semanticscholar.org/paper/1854b8800aa62981f9489133e2c77cffc29b57aa
7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893524/
8. https://arxiv.org/abs/1907.12612