Monthly Archives: June 2014

Water Damaged Buildings and Occupant Health

Depressed, Mental Issues – If You Think You’re a Nutcase, Just Maybe You’re Not

Studies on occupants from WDB have identified innate immune inflammatory abnormalities to include complement activation (C4a) as well as lower levels of a critical inflammatory regulator MSH (Melanocyte stimulating hormone).

This inflammatory basis of illness has been termed as a Chronic Inflammatory Response Syndrome (CIRS-WDB).

Clinical studies have shown those with CIRS once removed from site and treated, their abnormalities re-appear rapidly within three days of re-exposure to a microbial contaminated environment. (Ref 1)

VEGF (Vascular endothelial growth factor) can increase permeability of the blood brain barrier to biological toxins, research has shown that bacteria found in WDB like Strepotmyces also produce toxins which alter the blood brain barrier permeability, allowing possibly penetration of fungal mycotoxins like Glicotoxins from some Aspergillus species (mould). Inflammatory markers like TGF-beta 1 also can increase the permeability of the blood brain barrier.

The above suggests that when there is an increase in permeability of the blood brain barrier due to a bacterial exposure, the impact of the fungal toxins may be far greater than has been previously documented. In turn when there is both bacteria and fungi-in an attempt to survive fungi may produce far greater amounts of fungal mycotoxins to combat the bacteria.

A paper about to be published by Ritchie C. Shoemaker, Dennis House and James C. Ryan outlines the abnormalities of those with CIRS and confirms structural changes in the CNS (central nervous system) do occur in those with CIRS and that the above researchers have current studies underway, looking to expand on the significant structural abnormalities in brains of CIRS patients.

In layman’s terms what is being shown in the above, is that the rubbish produced by mould and bacteria in WDB can impact indirectly on the central nervous system and with the proper blood testing can be shown in the inflammatory markers.

In the world of those affected by mould and bacteria and where they have been informed that its all in their head, these findings suggest perhaps there are other pathways which maybe explored to the benefit of the affected individual.

References

  1. A Time Series Study of Sick Building Syndrome: Chronic, Biotoxin – Associated Illness From Exposure to Water-Damaged Buildings – Neurotoxicology and Teratology 27 (2005) pages 29-46.
  2. VEGF Increases Blood Brain Barrier Permeability to Evans Blue Dye and Tetanus Toxin fragment C – Brain Research 1234(2008) 198-205.

At Last The Blood Tests Developed For Dr Ritchie Shoemaker Are Here in Australia

The following are blood tests developed for Dr Ritchie Shoemaker in looking at CIRS – Chronic Inflammatory Response Syndrome – can be carried out in Melbourne, these tests would be looking for elevated TGF?-1, C4-a, C3-a, and low levels of MSH and VIP, which may provide your physician with results which can be used to determine CIRS.

CIRS may not just be associated with your home but your work environment and all too often people do not recognise there is an issue until they have run out of medical opinions, so please understand microbial exposures can be hidden and bacterial contamination cannot be seen by the naked eye.

Affected individuals with CIRS patients lose control of inflammatory pathways as levels of regulatory neuropeptides VIP and MSH decline, further adding to the inflammatory burden. Abnormal activation of MBL pathway of complement (Wallis, 2008) and elevated TGF beta-1 (Vignali, 2008) add to systemic inflammation and loss of normal regulatory T-cell function, 4 respectively.

These tests will be offered shortly here in Australia once validation has been completed.

Understanding These Tests
VEGF – Vascular endothelial growth factor suggested greater than 31 or less than 86- Astrocyte-derived VEGF-A drives blood brain barrier disruption in CNS inflammatory disease (Journal of Clinical investigation 122 (2012) 2454-68)

MSH – Melanocyte stimulating hormone- suggested threshole is greater than 36-MSH below 36 pg/ml has been associated with those suffering from Chronic fatigue Syndrome pg/ml. This important molecule helps regulate the immune system

C4a – can alter the blood brain barrier

VIP – Vasoactive intestinal polypeptide

MMP – Matrix metalloproteinase 9 – it’s an inflammatory marker involved in many degenerative processes- any levels above 332 ng/mL is considered to be elevated

ADH -ADH determines how often we pee and how concentrated our urine is.

Naturally the above information is simply to provide some understanding which up until now has not really being available here in Australia, this in no way promotes a medical opinion and should be used in conjunction with your treating medical doctor.

For those who like to understand more you might like to search a current paper written by Dr Ritchie Shoemaker “Innate immunity, MR spectroscopy, HLA DR, TGF beta-1, VIP and capillary hypoperfusion define acute and chronic human illness acquired following exposure to water-damaged buildings.”

A copy of that paper’s summary is below.

SUMMARY
Progress in understanding host innate immune inflammatory responses has led to advances in diagnosis and treatment of patients with illness acquired following exposure to the interior environment of water-damaged buildings (WDB). Profiling cases compared to controls based on innate immunity abnormalities that are correlated with measures of capillary hypoperfusion resulted in accurate classification. WDB-illness is a complex syndrome of absent or deficient regulatory neuropeptides MSH and VIP, elevated C4a, TGF beta-1 cytokines and hormonal dysregulation. Use of symptom rosters, visual contrast sensitivity testing and genetic markers adds to diagnostic certainty. Treatment modalities that correct these abnormalities lead to symptom reduction and clinical improvement.

Cheers and Good Health
Vince Neil
Mycotox

Soothing and Delicious Slow Cooked Broth for Stomach Problems

Chicken or Beef Broth

It’s so simple a broth which assists in providing beta glucans in high dose levels at a very very low cost. For years our mothers new about chicken broth but perhaps didn’t know or understand its high levels of Beta glucans actually produces the wondrous results. Nicholas DiLuzio of Tulane University, stated “The broad spectrum of immunopharmacological activities of glucan includes not only the modification of certain bacterial, fungal, viral, and parasitic infections, but also inhibition of tumor growth.”

This in layman’s terms means it assists in fighting disease of the immune system and 3 chicken carcasses cost about $3.00 and last for the week.

Recipe

  • You need a slow cooker so that you don’t breakdown the Glucans then add:
  • 3 chicken carcasses (free range at least)
  • Fill the slow cooker with water
  • Add salt and pepper to taste
  • Add fresh herbs whatever rows your boat
  • Garlic if you have no allergies
  • Chillies if your diet allows
  • We throw in a carrot and some shallots

Cook the pot for at least 3 days, then strain the contents into a stainless steel bowel, sit in the fridge to allow separation of the fat which will settle to the top, restrain with muslin and start sipping the idea is not ours but we thought it worthwhile sharing. Of course you can buy these additives of the shelf but fresh is best.

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